Small molecule compounds that modulate the fibrinolytic system
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چکیده
منابع مشابه
Small Molecule Therapeutics Small Molecule BMH-Compounds That Inhibit RNA Polymerase I and Cause Nucleolar Stress
Activation of the p53 pathway has been considered a therapeutic strategy to target cancers. We have previously identified several p53-activating small molecules in a cell-based screen. Two of the compounds activated p53 by causing DNA damage, but this modality was absent in the other four. We recently showed that one of these, BMH-21, inhibits RNA polymerase I (Pol I) transcription, causes the ...
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متن کاملSmall molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress.
Activation of the p53 pathway has been considered a therapeutic strategy to target cancers. We have previously identified several p53-activating small molecules in a cell-based screen. Two of the compounds activated p53 by causing DNA damage, but this modality was absent in the other four. We recently showed that one of these, BMH-21, inhibits RNA polymerase I (Pol I) transcription, causes the ...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 2010
ISSN: 1880-8808,0915-7441
DOI: 10.2491/jjsth.21.3